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Literature summary extracted from

  • Sun, J.; Xu, Y.; Gao, R.; Lin, J.; Wei, W.; Srinivas, S.; Li, D.; Yang, R.-S.; Li, X.-P.; Liao, X.-P.; Liu, Y.-H.; Feng, Y.
    Deciphering MCR-2 colistin resistance (2017), mBio, 8, e00625 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.43 D463A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli
2.7.8.43 E244A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli
2.7.8.43 H393A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli
2.7.8.43 H464A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli
2.7.8.43 H476A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli
2.7.8.43 additional information domain swapping between isoforms Mcr1 and Mcr2 shows that the presence of the resultant two chimeric genes can confer resistance of the colistin-susceptible strain MG1655 to up to 16 mg/liter of colistin Escherichia coli
2.7.8.43 T283A mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Escherichia coli A0A1C3NEV1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Escherichia coli diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 MCR2
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.7.8.43 physiological function a 6-residue-requiring zinc-binding/catalytic motif is essential for MCR2-mediated colistin resistance. The transmembrane regions TM2 and TM1 play a critical role in MCR2-mediated colistin resistance, catalytic activity depends on the correct location of MCR2 in bacterial periplasm Escherichia coli